High Blood Pressure Clinical Trial
Enrolling Now

Clinics: Greater Manchester Early Phase

Therapy Area: Hypertension

Gender and Age: Males & Females aged 18 – 65

Reimbursement: Up to £3460 plus reasonable travel expenses or transport provided

About The Research...

MAC Clinical Research is currently conducting a clinical trial to evaluate an investigational drug for hypertension (high blood pressure). Untreated hypertension can increase the risk of several other health problems, including heart attack, so it is important to treat high blood pressure (BP). While several treatments already exist, many patients do not respond adequately to these BP medications and research to discover better treatments is needed.

This trial will test the safety and efficacy of receiving either an injection of study medication and placebo tablet or placebo injection and irbesartan tablet in patients with high blood pressure. The study medication or placebo injection will be given once and will be given as 1 injection with a thin needle under the skin of either the abdomen, upper arm or thigh. Participants will be allocated to receive either ALN-AGT01 + tablet placebo or placebo injection + irbesartan.

There will be approx. 18 x outpatient visits plus 2 x 2-night residential stays over a period of up to 18 months. There is no certainty that you will receive any medical benefit from taking part in this study.

A full description of the study will be given before you decide to take part, both over the phone and during an appointment at a MAC clinic. This will include you receiving the full patient information sheet and an opportunity to ask the study doctor any questions.

Reimbursement:  Up to £3460 plus reasonable travel expenses or transport provided


Key Inclusion Criteria:

  • Male or female aged 18 to 65
  • Diagnosis of hypertension
  • BMI between > 35 and ≤ 50 kg/m2


Key Exclusion Criteria:

  • Diagnosis of early onset diabetes
  • Other unstable health condition
  • Current smoker


Other eligibility criteria will apply. Please contact MAC for more information.

Key Inclusion Criteria


Key Exclusion Criteria


MAC Clinical Research is conducting a trial to evaluate a potential new treatment for high blood pressure.

If you would like more information, please fill in the form below and we will be in touch…

Alternatively, please call our recruitment team on freephone 0800 633 5507.

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