Major Depression

Reimbursement: Up to £2190  

About This clinical research study

Despite the availability of numerous methods of medical and psychological treatments, fewer than 50% of all patients with depression show full recovery with optimised treatment such as CBT and depression medications.

MAC Clinical Research is conducting a clinical trial for people with depression who have tried two standard depression treatments (including therapy), but do not feel that they have worked sufficiently to reduce their depression symptoms.

The study medication SPL026 (DMT fumarate), a psychedelic compound which is similar to psilocybin, the psychedelic component of magic mushrooms, will be compared to a placebo (inactive medication) for its effects on treating depression. The study involves two sessions.

Researching into psychedelic compounds to treat depression in a controlled, clinical environment may go on to provide alternative depression treatment options for people with treatment resistant depression.

Reimbursement: Up to £2190



Therapy Area


Gender and Age

Males and Females aged 18 +

A full description of the study will be given before you decide to take part, both over the phone and during an appointment at a MAC clinic. This will include you receiving the patient information sheet and an opportunity to ask the study doctor any questions.

If you contact us, it does not mean you have to decide at that point whether to participate.
If you do decide to participate you are free to withdraw at any time.

The study will be split into two sessions.

• In Session 1, you will receive a dose of DMT or placebo.
• In Session 2, you will receive a dose of DMT.

Support will be given by trained therapists before, during and after the visits to the clinic.

Reimbursement: Up to £2190

Key Inclusion Criteria

Key Exclusion Criteria

Other eligibility criteria will apply. Please contact MAC for more information.

If you are eligible, you will receive a comprehensive health screen. Your GP will be fully informed of your participation and provided with any information relevant to your healthcare


Clinical research studies are performed as a way of bringing about progress in medicine and research. Clinical research studies make it possible to scientifically assess the properties of a drug, to demonstrate the effectiveness and safety of a treatment or a medical device, or to learn more about a disease and methods to diagnose and monitor it.

If the study is successful, it may be an important step towards developing a promising new treatment.

MAC Clinical Research is conducting a trial to evaluate a potential new treatment for depression

If you would like more information, please fill in the form below and we will be in touch…

Alternatively, please call our recruitment team on freephone 0800 633 5507.

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