Many people living with Parkinson’s may feel that the beneﬁts of their medication begin to fade away and do not last until their next dose – this is known as ‘wearing off.’
When those living with Parkinson’s experience an “off period” with their treatment, their symptoms start to come back or can worsen. The control of both motor and non-motor symptoms fluctuates like the tremor, muscle spasms and stiffness, or the anxiety and tiredness.
‘Wearing off’ tends to happen more frequently as the condition progresses, and when it does, the control of symptoms changes. As ‘wearing off’ becomes more frequent it may become increasingly difficult to control symptoms and predict when medications will work.
Wearing off can be unique to each person. In some people, motor symptoms such as the tremor may be the first sign, whilst for others it might be the non–motor symptoms in the form of increased anxiety, tiredness, a change in mood, difficulty thinking, and restlessness.
Dr Penny Foulds, neuroscience team leader at MAC Clinical Research said: “There is an unmet need for more effective treatments for the symptoms of Parkinson’s, Parkinson’s dementia and Dementia with Lewy Bodies.
“Through clinical research, we can develop better treatments and potentially help thousands of people around the world.”
MAC Clinical Research are currently recruiting for a trial involving the repurposing of an existing drug (developed for asthma), in the hope of providing new treatments for people with some brain disorders.
If you or a loved is currently living with:
• Parkinson’s with Memory Problems (Aged 50-80)
• Dementia with Lewy bodies (Aged 50-80)
• Parkinson’s dementia (Aged 50-80)
• Parkinson’s with REM sleep disorder (Aged 40-80)
Then you could be eligible for MAC Clinical Research’s clinical trial. The clinical trial is running at MAC’s clinics in Lancashire, South Yorkshire, and Greater Manchester. To find out more or register your interest, click here.