Crohn's Disease / Ulcerative Colitis
Clinical Trials
Researching potential new treatments for Crohn’s Disease (CD) and Ulcerative Colitis (UC).
Improving quality of life
Key Information
Reimbursement
You may be compensated for your time or reasonable travel expenses will be reimbursed or transport provided
Gender and Age
Males and Females aged 18 - 75
Clinics
Greater Manchester, Lancashire, Merseyside, South Staffordshire, South Yorkshire and West Yorkshire
Not all trials are available at all clinics.
Health Check
Receive a free comprehensive health check
Register Your Interest
What Happens Next?
1. Sign Up
Register your interest on our website or over the phone
2. We'll Call You
Our study specialists will call you to discuss your health and check if the trial is suitable for you
3. Eligible?
If eligible, you will be booked in for a 'CHAT' where you'll receive a Patient Information Sheet (PIS)
4. Medical History
If you decide to take part, our medical team will obtain a copy of your medical history from your GP
5. Health Check
You will attend a free comprehensive health check with a MAC doctor and your eligibility will be confirmed
6. Enrollment
You will be enrolled onto the clinical trial and attend scheduled visits (Travel expenses or transport to clinic provided)
About our Ulcerative Colitis & Crohn's Disease Clinical Trials
Clinical trials are research projects, performed as a way of bringing about progress in medicine and research. If you have Crohn’s or colitis, you may be eligible to participate in one of our clinical trials. We are currently recruiting volunteers to take part in a Crohn’s Disease (moderate to severe) clinical trial and Ulcerative Colitis (mild/moderate to severe) clinical trials.
– Male or female aged 18 to 75
– Diagnosis of Crohn’s Disease or Ulcerative Colitis
– Active ulcerative colitis or active crohn’s disease
– Must be willing and able to comply with study restrictions and to remain at the clinic for the required duration and willing to return to the clinic for the follow-up visits
– Current participation in a clinical trial
Other eligibility criteria will apply. Please contact MAC for more information.
A full description of the clinical trial will be given before you decide to take part, during an appointment at a MAC clinic. This will include you receiving the patient information sheet and an opportunity to ask the clinical research doctor any questions.
There is no obligation to take part in a clinical trial and you are free to withdraw at any time.
Crohn’s Disease Clinical Trial
Purpose: To further assess the safety and effectiveness of the study drug compared to placebo (a ‘dummy medication’ containing no active ingredient or drug) in participants with moderate to severe Crohn’s disease. Administration of the study drug or placebo is by tablet, taken orally, twice a day (morning and evening).
Duration: If you choose to participate you may be involved in the clinical study’s 5 phases, for a duration of up to 112 weeks (just over 2 years) which may include up to 25 outpatient visits.
Ulcerative Colitis Clinical Trials
Purpose (mild to severe UC): To test the safety and efficacy of PT101, compared to placebo (a ‘dummy medication’ containing no active ingredient or drug). Administration of the study drug or placebo is by subcutaneous (under the skin) injection.
Purpose (moderate to severe UC): To test whether PRA023 is safe and effective in treating ulcerative colitis, compared to placebo (dummy medication). Administration of the study drug or placebo is by intravenous (into the vein) infusion.
You may be compensated for your time or reasonable travel expenses will be reimbursed or transport provided (amount of reimbursement depends on the study and your level participation).
Frequently Asked Questions
Ulcerative colitis and Crohn’s disease are the most common forms of Inflammatory bowel disease (IBD), an umbrella term for a group of intestinal disorders causing inflammation of the digestive tract. Both are long-term conditions, often developing in teenagers or young adults and symptoms can be similar including, but not limited to, diarrhoea, rectal bleeding, stomach cramps and fatigue. Some of the key differences between these conditions are: ulcerative colitis is limited to the large intestine (colon), but Crohn’s can occur anywhere in the digestive tract between the mouth and anus, also Crohn’s can leave healthy parts of the intestine between inflamed areas, whereas ulcerative colitis leaves a continuous line of inflammation in the colon.
All clinical trials must be reviewed and authorised by various governing bodies and committees before they can go ahead to minimise any risks. The Medicines and Healthcare products Regulatory Agency (MHRA) ensures that medicines meet applicable standards of safety, quality and efficacy, meaning a trial must be thought to be safe before it is approved. The Health Research Authority (HRA) is responsible for research ethics committees across the UK. Independent research ethics committees work to protect the interests and rights of volunteers who take part in the trial, adding another layer of protection to the process.
Clinical trials go through a series of phases to test new investigational medicines and assess whether they are safe and effective. These investigational medicines are tested against another treatment, called a control, which is either a placebo (a dummy treatment with no active ingredients) or a standard treatment already in use. Volunteers are randomly assigned to receive either the investigational medicine or the control treatment, these groups are often referred to as cohorts. Researchers monitor the effects of the investigational and control treatments within participants to assess the safety and efficacy of the treatments administered.
Clinical drug trials help doctors to discover new ways to treat a particular illness and are a crucial step in advancing medicine. Volunteers who take part in clinical trials can help to advance medical treatments for a condition, which could benefit themselves as well as other people in the future, however, there is no guarantee that the clinical drug trial will be a success or improve the volunteer’s symptoms. In some cases, the drug trialled may be no better or worse than their current treatment. Clinical trials test the safety and efficacy of new drugs and so involve potential risks, and it is crucial that volunteers fully understand what is involved in the clinical trial before agreeing to take part. Volunteers for clinical trials are always screened to assess their suitability for the trial and will be fully informed of the risks associated with the trial during this screening process.