Ibogaine in Recreational Opioid Users

Clinics: Greater Manchester Early Phase Unit

Therapy Area: Recreational Opioid Users

Gender and Age: Males and Females aged 21 – 55

Reimbursement: £1200 in cash plus reasonable travel expenses or transport provided.

About The Research...

Do you take opioids recreationally for pleasure rather than for pain?

The purpose of this trial is to test a medication called Ibogaine. Ibogaine is being researched for the treatment of acute opioid withdrawal symptoms and to ease withdrawal of opioid use. The overall aim is to reduce or stop opioid use, prevent potential future harm associated with opioid use, and improve the quality of life and well‑being of opioid-dependent patients.

Following a successful medical screen and upon review of medical history, a minimum of 30 non-dependent recreational opioid users with a history of hallucinogen experience while using drugs will take one oral dose of Ibogaine and attend 8 outpatient visits and one 6-night residential stay at the Manchester Early Phase clinic. The study will last approx. 2 months

A full description of the study will be given before you decide to take part, both over the phone and during an appointment at a MAC clinic. This will include you receiving the full patient information sheet (PIS) and the opportunity to discuss the study in depth with a doctor. Your GP will also be notified of your participation.

Clinical research projects are performed as a way of bringing about progress in medicine and research. Clinical research projects make it possible to scientifically assess the properties of a drug, to demonstrate the effectiveness and safety of a treatment or a medical device, or to learn more about a disease and methods to diagnose and monitor it. If the study is successful it may provide alternative treatment options for opioid users looking to find a safe and effective method of detoxification.

If you contact us it does not mean you have to decide at that point whether to participate. If you do decide to participate you are free to withdraw at any time.

Reimbursement: £1200 in cash plus reasonable travel expenses or transport provided.


Key Inclusion Criteria:

  • Male or Females who are post-menopausal or surgically sterile
  • Age 21 to 55
  • BMI 18 – 28 kg/m2
  • Recreational opioid use (opioid is not prescribed or used to treat a medical condition)
  • A history of at least one hallucinogenic experience whilst on drugs


Key Exclusion Criteria:

  • Heavy smokers or vapers
  • Dependency on drugs (excluding caffeine) or alcohol
  • History of seizures or convulsions
  • History or presence of relevant cardiovascular disease
  • Current or ongoing/ COVID-19 or long COVID syndrome


Other eligibility criteria will apply. Please contact MAC for more information.

Any other information

If you are eligible you will receive a comprehensive health screen. Your GP will be fully informed of your participation and provided with any information relevant to your healthcare.

Key Inclusion Criteria


Key Exclusion Criteria


If you would like more information, please fill in the form below and we will be in touch…

Alternatively, please call our recruitment team on freephone 0800 633 5507.

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